Mifepristone also known as RU-486 is a synthetically produced antiprogesterone agent which blocks the progesterone hormone during the early stage of pregnancy. Progesterone is a naturally derived hormone which prepares the lining of the uterus for the implantation of a fertilized egg and helps in maintaining this pregnancy. Without progesterone, the lining of the uterus breaks down, softens and bleeding occurs and so the fertilized egg could not implant in the uterus. Mifepristone also makes the cervix and uterus more sensitive to the effects of Misoprostol. The intake of Mifepristone is usually followed by Misoprostol.
Misoprostol is a synthetically derived prostaglandin E1 analog which is originally used to treat gastric ulcers but is now widely used for the termination of unintended pregnancies. It causes uterine contractions and opening of the cervix, therefore, aids in the expulsion of the products of conception inside the uterus.
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